How hydrogen sulfide affects copper metabolism in the body
Sulfide-regulated copper metabolism
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11076336
This study is looking at how hydrogen sulfide, a gas that can be found in the body, affects how our cells use energy and handle copper, especially in the gut, to help us understand the potential long-term effects of being exposed to high levels of this gas.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11076336 on ClinicalTrials.gov |
What this research studies
This research investigates the role of hydrogen sulfide (H2S) in regulating energy metabolism and its effects on copper metabolism within the body. It focuses on how varying levels of H2S influence the function of complex IV in the electron transport chain, particularly in intestinal epithelial cells exposed to high levels of H2S. The study aims to uncover the long-term metabolic consequences of chronic sulfide exposure and its impact on copper-binding proteins and mitochondrial function, which could have implications for various physiological systems.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting copper metabolism or those experiencing gastrointestinal issues related to hydrogen sulfide exposure.
Not a fit: Patients without any metabolic disorders or gastrointestinal conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into metabolic disorders related to copper and hydrogen sulfide, potentially improving treatment strategies for related conditions.
How similar studies have performed: While the specific intersection of sulfide and copper metabolism is relatively novel, related studies have shown promising results in understanding metabolic regulation through signaling molecules.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIESSL, JUTTA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: DIESSL, JUTTA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.