How hydrogen sulfide affects copper metabolism in the body
Official title: Sulfide-regulated copper metabolism
Funded at University of Michigan at Ann Arbor · NIH-11076336 · Data updated 2026-11-12
This study is looking at how hydrogen sulfide, a gas that can be found in the body, affects how our cells use energy and handle copper, especially in the gut, to help us understand the potential long-term effects of being exposed to high levels of this gas.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 2, 2024 |
| Project end | April 1, 2026 |
| Funding year | 2025 |
| Award (this year) | $76,756 |
| NIH project number | 5F32GM154404-02 |
| Project ID | NIH-11076336 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting copper metabolism or those experiencing gastrointestinal issues related to hydrogen sulfide exposure.
✕Less likely to help
Patients without any metabolic disorders or gastrointestinal conditions may not receive direct benefits from this research.
What this research studies
This research investigates the role of hydrogen sulfide (H2S) in regulating energy metabolism and its effects on copper metabolism within the body. It focuses on how varying levels of H2S influence the function of complex IV in the electron transport chain, particularly in intestinal epithelial cells exposed to high levels of H2S. The study aims to uncover the long-term metabolic consequences of chronic sulfide exposure and its impact on copper-binding proteins and mitochondrial function, which could have implications for various physiological systems.
Why it matters
Potential benefit: If successful, this research could lead to new insights into metabolic disorders related to copper and hydrogen sulfide, potentially improving treatment strategies for related conditions.
How similar studies have gone: While the specific intersection of sulfide and copper metabolism is relatively novel, related studies have shown promising results in understanding metabolic regulation through signaling molecules.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Diessl, Jutta — University of Michigan at Ann Arbor
- Study coordinator: Diessl, Jutta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.