How hyaluronan affects heart healing after a heart attack
Dynamic Role of Hyaluronan in Ventricular Remodeling
This study is looking at how a substance called hyaluronan helps the heart heal after a heart attack, focusing on how certain cells involved in repair produce it, and it aims to find ways to improve recovery for people who have had a heart attack.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-11021082 on NIH RePORTER |
What this research studies
This research investigates the role of hyaluronan, a key component of the extracellular matrix, in the healing process of the heart following a myocardial infarction (heart attack). The study focuses on how fibroblasts, which are crucial for tissue repair, produce hyaluronan and other components of the extracellular matrix during the healing process. By manipulating hyaluronan metabolism, researchers aim to understand its impact on collagen secretion and the formation of scar tissue. The findings could provide insights into how the heart remodels itself after injury and the potential for improving recovery outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a myocardial infarction and are undergoing recovery.
Not a fit: Patients who have not experienced a heart attack or have chronic heart failure unrelated to recent myocardial infarction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart healing and prevent complications after a heart attack.
How similar studies have performed: Previous research has shown that understanding the extracellular matrix can lead to significant advancements in cardiac care, suggesting that this approach has potential for success.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Little, Danielle T — University of Louisville
- Study coordinator: Little, Danielle T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.