How hyaluronan affects brain blood vessel cells during aging and injury
Official title: Regulation of brain vascular endothelial cell ferroptosis by hyaluronan
Funded at Oregon Health & Science University · NIH-11139321 · Data updated 2026-11-12
This study is looking at how a natural substance called hyaluronan can help protect the cells in your brain's blood vessels from damage that can lead to memory problems and dementia, and it aims to find new ways to keep your brain healthy as you age.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $471,885 |
| NIH project number | 1R21AG089920-01A1 |
| Project ID | NIH-11139321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cognitive impairment or those at risk for vascular-related dementia.
✕Less likely to help
Patients with cognitive impairment not related to vascular issues or those with other neurological conditions may not benefit from this research.
What this research studies
This research investigates how hyaluronan, a natural substance in the body, can protect brain blood vessel cells from a type of cell death called ferroptosis, which is linked to cognitive decline and dementia. The study focuses on understanding the mechanisms behind brain vascular injury and how it leads to the breakdown of the blood-brain barrier, which can cause inflammation and neurodegenerative diseases. By examining the role of hyaluronan and its interaction with specific receptors on blood vessel cells, the researchers aim to identify potential therapeutic strategies to prevent or mitigate damage in aging populations. Patients may be involved in studies that explore these mechanisms and the effects of hyaluronan treatment.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect brain health and prevent cognitive decline in older adults.
How similar studies have gone: Previous research has shown promising results in using hyaluronan to inhibit cell death in other contexts, suggesting potential for success in this area as well.
Where this research is happening
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Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Sherman, Larry S. — Oregon Health & Science University
- Study coordinator: Sherman, Larry S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.