How human stem cells remember their instructions for growth and development
Determinants of epigenetic inheritance in human stem cell fate decisions
This research explores how human stem cells pass on their unique instructions to new cells, focusing on a key protein often involved in adult acute myeloid leukemia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11115675 on NIH RePORTER |
What this research studies
This project aims to understand the "memory" system within our stem cells, called epigenetics, which helps them decide whether to make more of themselves or turn into specialized cells. Researchers are particularly interested in a protein called NPM1, which plays a role in this memory system and is frequently altered in adult acute myeloid leukemia (AML). By studying how these stem cells maintain their identity and function, we hope to learn more about what goes wrong in diseases like AML. This work uses laboratory methods to uncover the fundamental ways our blood stem cells work.
Who could benefit from this research
Good fit: This foundational laboratory research is not recruiting patients but aims to benefit those with blood cancers like acute myeloid leukemia through future discoveries.
Not a fit: Patients without blood cancers, particularly acute myeloid leukemia, may not see direct benefit from this specific foundational research.
Why it matters
Potential benefit: This work could lead to a better understanding of blood cancers like acute myeloid leukemia, potentially guiding the development of new treatments.
How similar studies have performed: Research into epigenetic mechanisms and the role of proteins like NPM1 in stem cell function and cancer is an active and promising field, with ongoing discoveries contributing to our understanding.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Escobar, Thelma — University of Washington
- Study coordinator: Escobar, Thelma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.