How human rhinovirus uses cell functions to replicate
Nuclear functions co-opted by human rhinovirus during replication in the cytoplasm of infected cells
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10904007
This study looks at how the common cold virus tricks our cells to help it make more copies of itself, and it's aimed at finding ways to stop the virus from spreading in our bodies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10904007 on ClinicalTrials.gov |
What this research studies
This research investigates how human rhinovirus, a common virus that causes colds, manipulates the functions of infected human cells to replicate itself. The study focuses on how the virus alters the normal transport processes within cells, moving proteins and RNA from the nucleus to the cytoplasm where it can efficiently reproduce. By analyzing the proteins involved in this process, researchers aim to understand the mechanisms that allow the virus to thrive and potentially identify targets for antiviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of acute respiratory infections, particularly those caused by rhinoviruses.
Not a fit: Patients with chronic respiratory conditions or those who do not exhibit acute viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral treatments that effectively target and inhibit the replication of rhinoviruses and other similar viruses.
How similar studies have performed: Previous research has shown success in understanding viral mechanisms in other picornaviruses, suggesting that this approach may yield valuable insights.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEMLER, BERT L — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SEMLER, BERT L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections, Animal Diseases