How human proteins control gene expression and its impact on diseases
Official title: Translational Control by Human Pumilio Proteins
Funded at University of Minnesota · NIH-10909895 · Data updated 2026-11-12
This study is looking at how two proteins, PUM1 and PUM2, help control the way our genes work, which could give us important clues about diseases like infertility, cancer, and developmental disorders, and help improve treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 18, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $379,675 |
| NIH project number | 5R01GM150468-02 |
| Project ID | NIH-10909895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with infertility issues, certain cancers, or developmental disorders related to PUM1 and PUM2 dysfunction.
✕Less likely to help
Patients with conditions unrelated to the functions of PUM1 and PUM2 may not receive any benefit from this research.
What this research studies
This research investigates the role of human RNA-binding proteins, PUM1 and PUM2, in regulating gene expression and their implications for various diseases. By examining how these proteins interact with messenger RNA (mRNA), the study aims to uncover the mechanisms behind their influence on protein production and the potential consequences of their dysfunction. Patients may benefit from insights into how these proteins contribute to conditions such as infertility, cancers, and developmental disorders, ultimately leading to improved treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for diseases linked to PUM1 and PUM2 dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the roles of RNA-binding proteins in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Goldstrohm, Aaron Charles — University of Minnesota
- Study coordinator: Goldstrohm, Aaron Charles
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.