How human genes are controlled while RNA is made
Probing co-transcriptional gene regulatory logics in human transcriptomes
This project looks at how human cells create different RNA messages from the same gene, which could help people with genetic or RNA-related conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11158906 on NIH RePORTER |
What this research studies
From a patient's perspective: researchers will study how pieces of genes are joined or read in different ways when cells make RNA. They will use genetic and molecular lab experiments, map RNA and DNA across human cells, and run large-scale computer analyses to find patterns. The team will focus on how splicing events can turn on nearby hidden promoters and create 'hybrid' exons used in different messages. Results will aim to explain basic rules that control gene output in human tissues.
Who could benefit from this research
Good fit: People who might be most relevant are those willing to provide blood or tissue samples, especially individuals with known genetic or RNA‑splicing disorders.
Not a fit: Patients seeking immediate treatment are unlikely to benefit directly because this is fundamental laboratory research rather than a clinical trial.
Why it matters
Potential benefit: If successful, this work could reveal how mis‑regulated RNA processing causes disease and point to new biomarkers or targets for future therapies.
How similar studies have performed: Previous genomic and molecular studies have shown links between splicing and transcription, but the specific role of 'hybrid' exons and nearby cryptic promoters is a newer area of study.
Where this research is happening
Boston, United States
- Boston University (Charles River Campus) — Boston, United States (Active)
Researchers
- Principal investigator: Fiszbein, Ana — Boston University (Charles River Campus)
- Study coordinator: Fiszbein, Ana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.