How human cells build ribosomes
Novel regulatory networks driving human ribosome biogenesis
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11328835
Mapping the cell machinery that makes ribosomes to help people with inherited ribosome disorders and some cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11328835 on ClinicalTrials.gov |
What this research studies
This project uses human cells in the lab to watch how the cell's ribosome factories (nucleoli) form and change. The team applies a quantitative image-based test and a genome-wide siRNA screen in human breast epithelial cells to find proteins that alter nucleolar number, and they are extending the work to include non-coding RNAs. Their goal is to define how ribosomes are made in different tissues and during development and to connect specific failures to inherited ribosomopathies and to cancers. The work is laboratory-based using human cell models rather than clinical trials, focusing on disease mechanisms that could guide future patient tests or treatments.
Who could benefit from this research
Good fit: People with inherited ribosome disorders (ribosomopathies) or cancers thought to involve ribosome defects would find this research most relevant.
Not a fit: Patients whose conditions are unrelated to ribosome production are unlikely to see direct benefits from this work in the near term.
Why it matters
Potential benefit: Could reveal new targets or biomarkers for diagnosing and treating ribosomopathies and cancers linked to ribosome dysfunction.
How similar studies have performed: The investigators have published prior successful cell-based assays and screens that identified ribosome-related factors, but translating these findings into therapies is still early-stage.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BASERGA, SUSAN J — YALE UNIVERSITY
- Study coordinator: BASERGA, SUSAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers