How human antibodies affect brain signaling in autoimmune encephalitis
Impact of human anti-NMDA receptor antibodies on glutamate receptor signaling, calcium mobilization, and hippocampal neuronal circuits in autoimmune encephalitis
This study is looking at how certain antibodies in the body affect brain function in people with autoimmune encephalitis, with the hope of finding new ways to help improve treatments for those dealing with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10674739 on NIH RePORTER |
What this research studies
This research investigates the role of human antibodies that bind to neuronal proteins in autoimmune encephalitis, a condition that affects brain function. By studying how these antibodies influence glutamate receptor signaling and calcium mobilization in brain circuits, the research aims to uncover the underlying mechanisms of the disease. The approach includes advanced techniques such as proteomics and live cell microscopy to observe these interactions in real-time. The ultimate goal is to identify new therapeutic targets that could lead to better treatments for patients suffering from neurological diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune encephalitis or those exhibiting symptoms related to this condition.
Not a fit: Patients with neurological conditions unrelated to autoimmune encephalitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies for autoimmune encephalitis and related neurological disorders.
How similar studies have performed: Previous research has shown promise in understanding autoimmune mechanisms in neurological diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Benavides, David Roger — University of Maryland Baltimore
- Study coordinator: Benavides, David Roger
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.