How human and herpesvirus DNA copying machines work
DNA Replication Machines: Structure-Function Studies
['FUNDING_OTHER'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-11226588
Researchers will map the molecular machines that copy human DNA and herpes simplex virus DNA to help guide future treatments for replication-related diseases and viral infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-11226588 on ClinicalTrials.gov |
What this research studies
From my perspective as a patient, the team will study the shapes and interactions of the proteins that copy DNA in our cells and in the herpes simplex virus. They will focus on the main human DNA polymerases and the viral proteins that form and operate at the replication fork, revealing step-by-step how copying is coordinated. The work uses detailed structure-function experiments to fill in missing mechanisms that explain how high-fidelity replication and viral copying occur. Understanding these mechanisms could point scientists to new ways to stop viral replication or fix replication errors.
Who could benefit from this research
Good fit: People with recurrent HSV-1 infections or with conditions linked to DNA-replication defects would be most likely to be affected by the findings or be potential future trial candidates.
Not a fit: Those with health problems unrelated to DNA replication or herpesvirus infection are unlikely to see direct benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could lead to new antiviral drugs and therapies that address diseases caused by DNA replication errors.
How similar studies have performed: Previous structural studies of replication proteins have provided key insights, but important details remain missing, so this work builds on prior successes while addressing unresolved questions.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAHIROV, TAHIR H — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: TAHIROV, TAHIR H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.