How HSV-1 affects inflammation and aging in female mice.
HSV-1 preferentially induces neuroinflammation and senescence in female mice.
['FUNDING_R21'] · OKLAHOMA STATE UNIVERSITY STILLWATER · NIH-11023116
This study looks at how the HSV-1 virus affects inflammation and aging in female mice, especially how it can wake up from being inactive and impact their brains, with the goal of finding new ways to help people dealing with HSV-1 related issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA STATE UNIVERSITY STILLWATER (nih funded) |
| Locations | 1 site (STILLWATER, UNITED STATES) |
| Trial ID | NIH-11023116 on ClinicalTrials.gov |
What this research studies
This research investigates how the HSV-1 virus, which infects a large portion of the adult population, causes inflammation and aging-related changes specifically in female mice. The study focuses on the virus's ability to reactivate from latency in the nervous system and its effects on brain regions associated with sensory processing and stress response. By examining the differences in response between male and female mice, the research aims to uncover important biological mechanisms that could inform future treatments for HSV-1 related conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be adult females who have a history of HSV-1 infection.
Not a fit: Patients who are male or those without a history of HSV-1 infection may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for conditions related to HSV-1 infection, particularly in women.
How similar studies have performed: Previous research has shown that studying viral infections and their effects on the nervous system can yield significant insights, suggesting that this approach may be promising.
Where this research is happening
STILLWATER, UNITED STATES
- OKLAHOMA STATE UNIVERSITY STILLWATER — STILLWATER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JONES, CLINTON J — OKLAHOMA STATE UNIVERSITY STILLWATER
- Study coordinator: JONES, CLINTON J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection