How HSV-1 affects inflammation and aging in female mice.
Official title: HSV-1 preferentially induces neuroinflammation and senescence in female mice.
Funded at Oklahoma State University Stillwater · NIH-11023116 · Data updated 2026-11-12
This study looks at how the HSV-1 virus affects inflammation and aging in female mice, especially how it can wake up from being inactive and impact their brains, with the goal of finding new ways to help people dealing with HSV-1 related issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma State University Stillwater NIH-funded |
| Lab location | 1 site (Stillwater, United States) |
| Project start | February 2, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $181,390 |
| NIH project number | 5R21AI178282-02 |
| Project ID | NIH-11023116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be adult females who have a history of HSV-1 infection.
✕Less likely to help
Patients who are male or those without a history of HSV-1 infection may not receive any benefit from this research.
What this research studies
This research investigates how the HSV-1 virus, which infects a large portion of the adult population, causes inflammation and aging-related changes specifically in female mice. The study focuses on the virus's ability to reactivate from latency in the nervous system and its effects on brain regions associated with sensory processing and stress response. By examining the differences in response between male and female mice, the research aims to uncover important biological mechanisms that could inform future treatments for HSV-1 related conditions.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for conditions related to HSV-1 infection, particularly in women.
How similar studies have gone: Previous research has shown that studying viral infections and their effects on the nervous system can yield significant insights, suggesting that this approach may be promising.
Where this research is happening
-
Oklahoma State University Stillwater
Stillwater, United States Active
Researchers
- Principal investigator: Jones, Clinton J — Oklahoma State University Stillwater
- Study coordinator: Jones, Clinton J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.