How HPV replication relies on DNA repair pathways
Official title: HPV replication and its dependence on repair pathways
Funded at Northwestern University at Chicago · NIH-11001501 · Data updated 2026-11-12
This study is looking at how human papillomavirus (HPV) grows in skin cells and how certain DNA repair processes help it do that, with the goal of finding new ways to treat HPV-related health issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 15, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $194,000 |
| NIH project number | 5R21AI180285-02 |
| Project ID | NIH-11001501 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with HPV infections, particularly those at risk for HPV-related cancers.
✕Less likely to help
Patients who are not infected with HPV or those with conditions unrelated to HPV may not benefit from this research.
What this research studies
This research investigates how human papillomaviruses (HPV) replicate by linking their life cycle to the differentiation of host cells in the skin. It focuses on the mechanisms by which HPV-infected cells transition from the basal layer to the upper layers of the skin, where they replicate viral DNA. The study examines the role of specific DNA repair pathways, particularly the ataxia telangiectasia and Rad3-related (ATR) pathway, in facilitating this replication process. By understanding these mechanisms, the research aims to identify potential therapeutic targets for HPV-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for HPV infections and related cancers.
How similar studies have gone: Previous research has shown success in targeting DNA repair pathways in other viral infections, suggesting potential for similar breakthroughs with HPV.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Laimins, Laimonis a. — Northwestern University at Chicago
- Study coordinator: Laimins, Laimonis a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.