How HPV affects skin cell development and cancer risk
Human Papillomavirus Manipulation of Epithelial Differentiation
This study looks at how certain proteins from high-risk HPV can change the way skin cells grow and survive, which might lead to cancer, and it aims to find new ways to treat or prevent this.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11190422 on NIH RePORTER |
What this research studies
This research investigates how high-risk human papillomavirus (HPV) alters the normal development of skin cells, which can lead to cancer. The study focuses on the role of specific HPV proteins, particularly E6 and E7, in manipulating the cellular environment to promote cell growth and prevent cell death. By understanding these mechanisms, researchers aim to uncover how HPV contributes to cancer progression and identify potential targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with high-risk HPV infections who are at increased risk for developing related cancers.
Not a fit: Patients with low-risk HPV infections or those who do not have HPV-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating HPV-related cancers.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of HPV-related oncogenesis, indicating that this approach has potential for significant findings.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: White, Elizabeth a — Tufts University Boston
- Study coordinator: White, Elizabeth a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.