How HPV affects cell behavior in the skin and its role in cancer development
Official title: Human papillomavirus regulation of the Hippo signaling pathway
Funded at Tufts University Boston · NIH-11124406 · Data updated 2026-11-12
This study is looking at how a specific part of the HPV virus affects skin cells, which could help us understand why some HPV infections stick around and how they might lead to cancer, with the hope of finding better ways to prevent or treat HPV-related cancers for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $533,707 |
| NIH project number | 1R01AI182668-01A1 |
| Project ID | NIH-11124406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with high-risk HPV infections or those at risk for HPV-related cancers.
✕Less likely to help
Patients who do not have HPV infections or are not at risk for HPV-related cancers may not benefit from this research.
What this research studies
This research investigates how high-risk human papillomavirus (HPV) maintains its presence in the basal layer of skin cells, which is crucial for understanding its role in cancer development. The study focuses on the HPV E7 protein and its interaction with cellular mechanisms that regulate cell growth and differentiation. By examining how HPV E7 disrupts normal cell processes, the research aims to uncover the underlying reasons for persistent HPV infections and their link to cancer. Patients may benefit from insights that could lead to new prevention or treatment strategies for HPV-related cancers.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancers associated with HPV.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of HPV and its role in cancer, indicating that this approach has potential for significant findings.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: White, Elizabeth a — Tufts University Boston
- Study coordinator: White, Elizabeth a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.