How household air pollution affects lung health in children
Official title: Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial
Funded at Icahn School of Medicine at Mount Sinai · NIH-11050352 · Data updated 2026-11-12
This study is looking at how air pollution at home during pregnancy and early childhood affects the germs and viruses in kids' bodies and their lung health as they grow, and it’s for families in Ghana who want to learn about ways to improve their children's health by reducing air pollution.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 17, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,377,026 |
| NIH project number | 1R01ES035791-01A1 |
| Project ID | NIH-11050352 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are pregnant women and infants living in low- and middle-income countries who are exposed to household air pollution.
✕Less likely to help
Patients who are not exposed to household air pollution or who are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research investigates the impact of household air pollution exposure during pregnancy and infancy on the microbiome and virome of children, and how these factors influence lung function as they grow. By utilizing a randomized controlled trial approach in Ghana, the study aims to assess the effects of interventions designed to reduce air pollution exposure on children's health outcomes. The research will employ validated methods to analyze changes in microbial communities and lung function over time, providing valuable insights into respiratory health in early childhood.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for reducing respiratory diseases in children exposed to household air pollution.
How similar studies have gone: Previous research has shown that interventions to reduce household air pollution can lead to significant health improvements, indicating a promising avenue for this study.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Lee, Alison G — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lee, Alison G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.