How host genetics influence gut bacteria populations
The Role of Host Genetics in Shaping Intestinal Lactobacillus Population
This study is looking at how our genes can affect the types of good bacteria, like Lactobacillus, in our gut by using a special mouse model, and it hopes to help us understand how these genetic differences might influence our overall health and immune system.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11059048 on NIH RePORTER |
What this research studies
This research investigates the impact of host genetics on the composition of gut bacteria, specifically focusing on Lactobacillus populations. Using a specialized mouse model, the study aims to eliminate environmental factors to isolate the genetic influences on the microbiome. By understanding these interactions, the research seeks to uncover how genetic variations can shape the gut microbiome and its functions, which are crucial for overall health and immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with genetic variations that may influence their gut microbiome composition, particularly those with autoimmune conditions.
Not a fit: Patients with established gut microbiome disorders unrelated to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized approaches in managing gut health and related immune conditions based on individual genetic profiles.
How similar studies have performed: Previous research has shown that host genetics significantly influences microbiome composition, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Lietuvninkas, Helen Beilinson — University of Chicago
- Study coordinator: Lietuvninkas, Helen Beilinson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.