How hospital-acquired pneumonia affects brain function
Official title: Nosocomial pneumonias impair cognitive function
Funded at University of South Alabama · NIH-10939762 · Data updated 2026-11-12
This study is looking at how pneumonia that you might get while in the hospital can affect your thinking and memory, especially if you've been in intensive care, by checking for harmful substances in your blood and spinal fluid.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project start | April 1, 2018 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $384,949 |
| NIH project number | 3R01HL140182-07S1 |
| Project ID | NIH-10939762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have experienced hospital-acquired pneumonia and are recovering from intensive care.
✕Less likely to help
Patients who have not been hospitalized or do not have a history of pneumonia may not benefit from this research.
What this research studies
This research investigates the link between hospital-acquired pneumonia and cognitive impairment in patients who have been in intensive care units. It focuses on understanding how infections from bacteria like Pseudomonas aeruginosa can lead to the release of harmful amyloids that affect brain function. By analyzing blood and cerebrospinal fluid from affected patients, the study aims to uncover the mechanisms behind cognitive decline following pneumonia. The research employs various laboratory techniques, including the use of cultured cells and brain slices, to explore these effects in detail.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of cognitive impairments in patients recovering from severe infections.
How similar studies have gone: Previous research has indicated a connection between infections and cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of South Alabama
Mobile, United States Active
Researchers
- Principal investigator: Lin, Mike T — University of South Alabama
- Study coordinator: Lin, Mike T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.