How hormones affect inflammation, sleep, and Alzheimer's disease risk in women
Role of estradiol and related hormones on inflammation, sleep, and risks for Alzheimer's disease
This study is looking at how hormones like estradiol affect inflammation, sleep problems, and the risk of Alzheimer's disease in middle-aged women, and it invites 150 women, both African American and Caucasian, to help us understand how these hormones might influence brain health over two years.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10663189 on NIH RePORTER |
What this research studies
This research investigates the impact of sex hormones, particularly estradiol and related hormones, on inflammation, sleep disturbances, and the risk of developing Alzheimer's disease (AD) in middle-aged women. The study will enroll 150 participants, including both African American and Caucasian women, to explore how variations in hormone levels influence known AD biomarkers and risk factors. By examining the relationship between these hormones and factors like sleep quality and brain blood flow, the research aims to uncover potential mechanisms that contribute to the increased risk of AD in women. Participants will be part of a two-year observational study that leverages existing cohorts to gather comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates for this research are middle-aged women, particularly those who are African American or Caucasian, who may be experiencing hormonal changes associated with menopause.
Not a fit: Patients who are not middle-aged women or those who do not have concerns related to hormonal changes or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for reducing Alzheimer's disease risk in women.
How similar studies have performed: Previous research has indicated a connection between sex hormones and Alzheimer's disease risk, suggesting that this approach has the potential for meaningful insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Wharton, Whitney Lee — Emory University
- Study coordinator: Wharton, Whitney Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.