How hormones affect breathing flexibility and control
Estrogen Receptor Signaling in the Expression of Respiratory Motor Plasticity
This study looks at how hormones like estrogen affect the brain's ability to change breathing patterns when the body needs it, which could help improve breathing for people with respiratory issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11009054 on NIH RePORTER |
What this research studies
This research investigates how gonadal hormones, particularly estrogens, influence the brain's ability to adapt breathing patterns in response to various physiological changes. The study focuses on the role of these hormones in spinal cord signaling and their impact on respiratory neuroplasticity. By examining the effects of hormone signaling on spinal microglia, the research aims to uncover mechanisms that could enhance or restore breathing flexibility. Patients may benefit from insights into how hormonal treatments could improve respiratory function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing respiratory difficulties, particularly those affected by hormonal imbalances.
Not a fit: Patients with stable respiratory function and no hormonal issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance breathing control in patients with respiratory issues.
How similar studies have performed: Previous research has shown that hormonal modulation can significantly impact neuroplasticity in other areas of the nervous system, suggesting potential success for this approach.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Dougherty, Brendan J — University of Minnesota
- Study coordinator: Dougherty, Brendan J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.