How hormone therapy affects motivation and emotions in prostate cancer patients

Effects of ADT on motivation and emotion function in prostate cancer patients: longitudinal imaging and prediction

NIH-funded research VA Connecticut Healthcare System · NIH-11043405

This study is looking at how hormone therapy for prostate cancer affects motivation and emotions in men, helping us understand the side effects they might face, like feeling more anxious or down, so we can better support their overall well-being during and after treatment.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionVA Connecticut Healthcare System NIH-funded
Lab location1 site (West Haven, United States)
Project IDNIH-11043405 on NIH RePORTER

What this research studies

This research investigates the effects of androgen deprivation therapy (ADT) on motivation and emotional function in men undergoing treatment for prostate cancer. It aims to understand the cognitive and physiological side effects associated with ADT, particularly how these may resemble accelerated aging. By using longitudinal imaging and predictive methods, the study seeks to identify variations in how patients respond to ADT, focusing on the potential development of anxiety, depression, and motivation deficits. This research is crucial for improving the management and care of prostate cancer patients, especially those who may be cured from cancer but experience significant side effects.

Who could benefit from this research

Good fit: Ideal candidates for this research are men diagnosed with prostate cancer who are receiving androgen deprivation therapy.

Not a fit: Patients who are not undergoing ADT or those with metastatic prostate cancer may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better management strategies for prostate cancer patients undergoing ADT, improving their quality of life.

How similar studies have performed: Previous research has indicated that hormone therapies can significantly impact cognitive and emotional health, suggesting that this approach may yield valuable insights.

Where this research is happening

West Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.