How hormone therapy affects motivation and emotions in prostate cancer patients
Official title: Effects of ADT on motivation and emotion function in prostate cancer patients: longitudinal imaging and prediction
Funded at VA Connecticut Healthcare System · NIH-11043405 · Data updated 2026-11-12
This study is looking at how hormone therapy for prostate cancer affects motivation and emotions in men, helping us understand the side effects they might face, like feeling more anxious or down, so we can better support their overall well-being during and after treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Connecticut Healthcare System NIH-funded |
| Lab location | 1 site (West Haven, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01CX001301-06 |
| Project ID | NIH-11043405 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men diagnosed with prostate cancer who are receiving androgen deprivation therapy.
✕Less likely to help
Patients who are not undergoing ADT or those with metastatic prostate cancer may not benefit from this research.
What this research studies
This research investigates the effects of androgen deprivation therapy (ADT) on motivation and emotional function in men undergoing treatment for prostate cancer. It aims to understand the cognitive and physiological side effects associated with ADT, particularly how these may resemble accelerated aging. By using longitudinal imaging and predictive methods, the study seeks to identify variations in how patients respond to ADT, focusing on the potential development of anxiety, depression, and motivation deficits. This research is crucial for improving the management and care of prostate cancer patients, especially those who may be cured from cancer but experience significant side effects.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for prostate cancer patients undergoing ADT, improving their quality of life.
How similar studies have gone: Previous research has indicated that hormone therapies can significantly impact cognitive and emotional health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
VA Connecticut Healthcare System
West Haven, United States Active
Researchers
- Principal investigator: Chao, Herta Huey-an — VA Connecticut Healthcare System
- Study coordinator: Chao, Herta Huey-an
Related research
Other NIH-funded projects on the same topics.
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Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
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Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.