How hormone therapy affects drug metabolism in transgender adults
Hormone mediated mechanisms of altered drug metabolism and transport in transgender adults
This study is looking at how hormone therapy, especially estradiol, affects how your body processes medications, and it's for transgender and gender diverse adults who want to ensure their treatments are safe and effective.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10899772 on NIH RePORTER |
What this research studies
This research investigates how hormone therapy, particularly estradiol, influences the metabolism and transport of medications in transgender and gender diverse adults. The study will utilize a framework involving probe substrates and biomarkers to assess changes in drug handling proteins before and during hormone treatment. By understanding these interactions, the research aims to improve drug safety and efficacy for individuals undergoing hormone therapy. Participants will contribute to advancing clinical strategies that address potential drug interactions and optimize treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are transgender and gender diverse adults who are receiving or considering hormone therapy.
Not a fit: Patients who are not undergoing hormone therapy or who are not transgender or gender diverse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective medication regimens for transgender adults undergoing hormone therapy.
How similar studies have performed: Other research has shown promising results in understanding drug interactions in transgender populations, making this approach both relevant and necessary.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Cirrincione, Lauren — University of Washington
- Study coordinator: Cirrincione, Lauren
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.