How hormonal changes affect inflammation and pain sensitivity
The impact of hormonal modulation on systemic inflammation and central sensitization
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10932848
This study is looking at how hormones affect chronic pelvic pain, especially for those with endometriosis, and it will test a medication called elagolix to see if it helps reduce pain and inflammation in the body.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10932848 on ClinicalTrials.gov |
What this research studies
This research investigates the role of hormonal modulation in chronic pelvic pain, particularly focusing on endometriosis-associated pelvic pain (EAPP). It aims to understand how low-grade systemic inflammation contributes to pain sensitivity and the overall disease state. By using a medication called elagolix, the study will assess how hormonal suppression impacts both pelvic and systemic inflammation, as well as central nervous system sensitization. Patients may be monitored for changes in pain levels and related symptoms throughout the treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are women suffering from endometriosis-associated pelvic pain or chronic pelvic pain syndromes.
Not a fit: Patients with chronic pelvic pain not related to endometriosis or those who do not respond to hormonal treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for chronic pelvic pain, enhancing the quality of life for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between inflammation and pain sensitivity, suggesting that this approach may yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AS-SANIE, SAWSAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: AS-SANIE, SAWSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.