How hormonal changes affect inflammation and pain sensitivity
Official title: The impact of hormonal modulation on systemic inflammation and central sensitization
Funded at University of Michigan at Ann Arbor · NIH-10932848 · Data updated 2026-11-12
This study is looking at how hormones affect chronic pelvic pain, especially for those with endometriosis, and it will test a medication called elagolix to see if it helps reduce pain and inflammation in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $634,460 |
| NIH project number | 5R01HD108253-02 |
| Project ID | NIH-10932848 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women suffering from endometriosis-associated pelvic pain or chronic pelvic pain syndromes.
✕Less likely to help
Patients with chronic pelvic pain not related to endometriosis or those who do not respond to hormonal treatments may not benefit from this research.
What this research studies
This research investigates the role of hormonal modulation in chronic pelvic pain, particularly focusing on endometriosis-associated pelvic pain (EAPP). It aims to understand how low-grade systemic inflammation contributes to pain sensitivity and the overall disease state. By using a medication called elagolix, the study will assess how hormonal suppression impacts both pelvic and systemic inflammation, as well as central nervous system sensitization. Patients may be monitored for changes in pain levels and related symptoms throughout the treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for chronic pelvic pain, enhancing the quality of life for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between inflammation and pain sensitivity, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: As-Sanie, Sawsan — University of Michigan at Ann Arbor
- Study coordinator: As-Sanie, Sawsan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.