How HIV Rev protein affects gene expression in human cells
Effects of HIV Rev on Host Cell Gene Expression
This study is looking at how a protein from the HIV virus affects the way our cells use their genes, which could help us understand how HIV spreads and how our immune system responds, making it important for anyone interested in HIV research or treatment.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10673153 on NIH RePORTER |
What this research studies
This research investigates the role of the HIV Rev protein in altering gene expression within human cells. It aims to understand how Rev interacts with cellular RNA elements to facilitate the export of viral RNA, which may also impact the expression of cellular genes. By identifying cellular RNAs that interact with Rev, the study seeks to uncover novel RNA isoforms that could influence immune responses or promote viral replication. This research employs advanced techniques to isolate and analyze these interactions, potentially revealing new insights into HIV's effects on host cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may benefit from improved understanding and treatment of the virus's impact on their cellular functions.
Not a fit: Patients who are not infected with HIV or those who have already achieved viral suppression may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing HIV infection and its effects on the immune system.
How similar studies have performed: Previous research has shown success in understanding viral interactions with host cell mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Rekosh, David M — University of Virginia
- Study coordinator: Rekosh, David M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.