How HIV-related particles affect brain blood vessels
The effects of HIV-associated extracellular vesicles on mitochondrial dysfunction in brain microvessels
This project explores how tiny particles from HIV might damage blood vessels in the brain, contributing to memory and thinking difficulties in people with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11136378 on NIH RePORTER |
What this research studies
Even with effective HIV treatment, many individuals still experience challenges with memory and thinking, known as HIV-1 associated neurocognitive disorders (HAND). The exact causes of HAND are not fully understood, which makes developing new treatments difficult. This project focuses on tiny particles, called extracellular vesicles (EVs), released by HIV-infected cells, which appear to play a significant role. We believe these HIV-associated EVs damage the delicate blood vessels in the brain and disrupt the protective blood-brain barrier by interfering with how cells produce energy. By uncovering these specific mechanisms, we aim to pave the way for new treatments to protect brain health in people living with HIV.
Who could benefit from this research
Good fit: This foundational research is for patients living with HIV who experience or are at risk for neurocognitive disorders.
Not a fit: Patients without HIV or those whose neurocognitive issues are unrelated to HIV may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that protect brain health and improve thinking abilities for people living with HIV.
How similar studies have performed: Preliminary findings from this team and others suggest that extracellular vesicles play a role in various diseases, and this project offers novel insights into their specific impact on HIV-related brain issues.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Chandra, Partha — Tulane University of Louisiana
- Study coordinator: Chandra, Partha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.