How HIV changes in people with detectable virus and those on treatment
HIV Evolution Defines Virus-Host/Drug Interactions In Viremic and Aviremic People
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11328308
This work looks at how HIV evolves in people with and without detectable virus to find drug-resistant mutations and improve treatment choices.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11328308 on ClinicalTrials.gov |
What this research studies
From your perspective, researchers collect blood samples from people living with HIV who have detectable virus and from those whose virus is suppressed on ART. They use genetic sequencing and a combined phylodynamics test to tell how recently infections occurred and to find both high- and low-frequency drug resistance mutations. The team compares virus populations over time and between viremic and aviremic participants to see how resistant strains emerge and spread. Some samples may come from collaborating clinics, including locations in sub-Saharan Africa, to capture diverse viral strains.
Who could benefit from this research
Good fit: Adults living with HIV who can give blood samples, including people with detectable viral load and those on suppressive antiretroviral therapy, are the ideal candidates.
Not a fit: People without HIV or those whose treatment is already working perfectly and have no risk of resistance are unlikely to gain direct benefit from participating.
Why it matters
Potential benefit: If successful, this could help doctors pick HIV drugs that are less likely to fail by revealing low-level resistance and patterns of viral change.
How similar studies have performed: Genetic sequencing and phylodynamics have previously helped detect drug resistance, and the team has produced a combined assay in earlier work, so this builds on proven methods.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWANSTROM, RONALD I — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: SWANSTROM, RONALD I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus