How HIV and oral microbes affect the persistence of HPV in the mouth
Impact of HIV, oral microbiome and mycobiome on oral HPV persistence
This study is looking at how the germs in your mouth might affect the chances of getting and keeping certain types of HPV in people with and without HIV, using saliva samples to learn more about the connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10906245 on NIH RePORTER |
What this research studies
This research investigates the relationship between HIV, the oral microbiome, and the persistence of oral human papillomavirus (HPV) infections. By analyzing saliva samples from a large cohort of individuals living with HIV and those without, the study aims to understand how changes in oral bacteria and fungi may influence the risk of acquiring and maintaining high-risk HPV types. The approach includes advanced genetic sequencing techniques to profile the oral microbiome and mycobiome, providing insights into their roles in HPV-related oral diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV, as well as HIV-negative individuals, who are interested in understanding the impact of oral health on HPV persistence.
Not a fit: Patients who do not have HPV infections or are not at risk for HPV-related oral diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and managing oral HPV infections and related cancers in individuals living with HIV.
How similar studies have performed: Previous research has shown that the oral microbiome can influence HPV infections, suggesting that this study's approach may yield valuable insights.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Burk, Robert D — Albert Einstein College of Medicine
- Study coordinator: Burk, Robert D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.