How HIV and opioids interact to cause pain
Cooperative mechanisms of HIV and opiods in pain pathogenisis
This study is looking at how long-term use of pain medications called opioids might actually make pain worse for people living with HIV/AIDS, and it aims to find better ways to manage that pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10665625 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which chronic opioid treatment can worsen pain in patients with HIV/AIDS. It focuses on understanding how opioids, commonly used for pain relief, may lead to a heightened pain state known as hyperalgesia. Using a mouse model that mimics the pain conditions experienced by HIV patients, the study aims to identify the neuroinflammatory pathways that are activated by both HIV and opioids. By uncovering these mechanisms, the research seeks to improve pain management strategies for HIV patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV/AIDS patients who experience chronic pain and are currently using or have used opioid analgesics.
Not a fit: Patients who do not have HIV/AIDS or do not experience chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better pain management strategies for HIV patients, reducing the risk of opioid overdose and improving their quality of life.
How similar studies have performed: Previous research has indicated that understanding the interplay between opioids and HIV-related pain can lead to significant advancements in pain management, suggesting that this approach has potential for success.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Tang, Shao-Jun — State University New York Stony Brook
- Study coordinator: Tang, Shao-Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.