How HIV and opioid use affect the immune system
Immune Dysfunction in HIV+ Opioid Users
This study is looking at how HIV and opioid use affect the immune system's ability to respond to vaccines, and it's for people living with HIV who also use opioids, to help understand why their immune responses might be weaker.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11014316 on NIH RePORTER |
What this research studies
This research investigates the impact of HIV infection and opioid use on the immune system, particularly focusing on how these factors impair the body's ability to respond to vaccines. The study examines the immune responses of individuals living with HIV who also use opioids, identifying differences in antibody production and immune cell function. By analyzing the immune profiles of these patients, the research aims to uncover the mechanisms behind their weakened immune responses and how chronic opioid use exacerbates these issues. Participants may undergo assessments involving vaccinations to evaluate their immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are living with HIV and have a history of opioid use.
Not a fit: Patients who are not living with HIV or do not have a history of opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for HIV+ individuals who use opioids, enhancing their immune function and overall health.
How similar studies have performed: While the intersection of HIV and opioid use has been underexplored, previous studies have shown that addressing immune dysfunction in HIV can lead to significant improvements in patient outcomes, suggesting potential for success in this area.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Pahwa, Savita — University of Miami School of Medicine
- Study coordinator: Pahwa, Savita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.