How HIV and fentanyl affect brain cell damage and repair
NLRP inflammasome directed activation of the innate immune system produces synaptic damage in EcoHIV infected mice self-administering fentanyl
This study is looking at how HIV and fentanyl affect brain cells and cause problems with thinking and memory in people living with HIV, and it hopes to find ways to help repair the brain and improve cognitive function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10832647 on NIH RePORTER |
What this research studies
This research investigates the effects of HIV and fentanyl on brain cells, particularly focusing on how these factors lead to synaptic damage and cognitive impairments in people living with HIV. The study examines the role of the NLRP inflammasome pathway in astrocytes, which are crucial for brain health, and how this pathway contributes to inflammation and damage in the brain. By understanding these mechanisms, the research aims to identify potential targets for therapeutic interventions that could help repair synaptic damage and improve cognitive function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are also experiencing cognitive impairments and have a history of fentanyl use.
Not a fit: Patients who are not living with HIV or who do not have a history of substance use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help restore brain function and cognitive abilities in individuals living with HIV who are also struggling with substance use disorders.
How similar studies have performed: Previous studies have shown that understanding the interactions between HIV and drug use can lead to significant insights into cognitive impairments, suggesting that this research could build on established findings.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Haughey, Norman J — Johns Hopkins University
- Study coordinator: Haughey, Norman J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.