How HIV and antiretroviral therapy affect bone health
Impact of HIV and antiretroviral initiation on skeletal biology
['FUNDING_R21'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10872816
This study is looking at how HIV and different treatments affect bone health, especially the risk of osteoporosis and fractures, to help people living with HIV understand how their condition and medications might impact their bones.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10872816 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of HIV and different antiretroviral therapies on bone health, particularly focusing on osteoporosis and fractures. It involves a comprehensive longitudinal study comparing two specific treatment regimens and utilizes advanced imaging techniques like dual energy X-ray absorptiometry and high-resolution peripheral quantitative CT to assess bone density and strength. Additionally, the study will analyze bone biopsies to understand the cellular and molecular mechanisms behind bone loss in people living with HIV. The research aims to uncover how factors like proteinuria may contribute to bone fragility in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are living with HIV and undergoing antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that protect bone health in individuals living with HIV.
How similar studies have performed: Previous research has shown that understanding the effects of antiretroviral therapy on bone health can lead to significant advancements in patient care, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YIN, MICHAEL T — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: YIN, MICHAEL T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.