How HIV affects the transmission of a virus linked to a common cancer in HIV patients
Role of HIV in KSHV oral transmission
This study is looking at how having HIV affects the spread of a virus linked to a common cancer in people with HIV/AIDS, using a special lab model that simulates the mouth to see how the virus gets into the body, especially through saliva from HIV patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10916273 on NIH RePORTER |
What this research studies
This research investigates how the presence of HIV influences the transmission of Kaposi sarcoma herpesvirus (KSHV), which is associated with a common cancer in individuals living with HIV/AIDS. The study utilizes a 3-dimensional organotypic culture model that mimics the oral mucosa to better understand the initial infection process of KSHV. By examining the role of saliva-derived extracellular vesicles from HIV patients, the research aims to uncover how these vesicles enhance KSHV infectivity and transmission. This approach could provide insights into the mechanisms of viral transmission and infection in the oral cavity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV/AIDS who may be at risk for developing Kaposi sarcoma.
Not a fit: Patients who are not infected with HIV or those who do not have a risk of developing Kaposi sarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for Kaposi sarcoma in HIV-positive individuals.
How similar studies have performed: While the specific approach of using a 3-D organotypic culture model for KSHV transmission has not been extensively studied, related research has shown promise in understanding viral infections in similar contexts.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Jin, Ge — Case Western Reserve University
- Study coordinator: Jin, Ge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.