How HIV affects the early stages of tuberculosis infection in the lungs
Official title: Impact of HIV on the human alveolar environment drivingthe early events of Mycobacterium tuberculosis infection
Funded at Texas Biomedical Research Institute · NIH-10947931 · Data updated 2026-11-12
This study looks at how the bacteria that cause tuberculosis interact with the lungs of people who are also living with HIV, hoping to find new ways to help improve treatment for those dealing with both conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 16, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,011,348 |
| NIH project number | 1R01AI184581-01 |
| Project ID | NIH-10947931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are HIV-positive and at risk of developing tuberculosis.
✕Less likely to help
Patients who are not infected with HIV or those who do not have a risk of tuberculosis may not benefit from this research.
What this research studies
This research investigates the interactions between Mycobacterium tuberculosis (M.tb) and the alveolar environment in the lungs of individuals infected with HIV. It focuses on how the alveolar lining fluid and host cells interact with M.tb during the initial stages of infection, which is crucial for understanding the progression of tuberculosis. By examining these early events, the research aims to identify potential targets for intervention that could improve treatment outcomes for patients with both HIV and tuberculosis.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating tuberculosis in individuals living with HIV.
How similar studies have gone: Previous research has shown that understanding the interactions between pathogens and the host environment can lead to significant advancements in treatment strategies, suggesting that this approach has potential for success.
Where this research is happening
-
Texas Biomedical Research Institute
San Antonio, United States Active
Researchers
- Principal investigator: Torrelles, Jordi B — Texas Biomedical Research Institute
- Study coordinator: Torrelles, Jordi B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.