How HIV affects oral health in children
Dynamics of HIV-infection, Oral Innate Immunity and The Development of Oral Diseases in Children
This study is looking at how HIV affects oral health in children by checking their saliva to see if certain natural defenses can help prevent dental problems, and it's for kids getting care at a hospital in Kenya.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10653227 on NIH RePORTER |
What this research studies
This research investigates the relationship between HIV infection and oral diseases in children, particularly focusing on the role of salivary antimicrobial peptides (AMPs) in preventing dental issues. The study will follow a cohort of children receiving care at a major hospital in Kenya, assessing how HIV influences the development of oral diseases over a year. By analyzing saliva samples, researchers aim to understand the immune response in these children and its impact on their oral health. This collaborative effort between the University of Washington and the University of Nairobi leverages over two decades of experience in pediatric HIV research.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-14 living with HIV in Kenya.
Not a fit: Children who are not living with HIV or those outside the specified age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved oral health strategies for children living with HIV, potentially reducing the incidence of dental diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of AMPs in oral health, but this specific focus on HIV-infected children is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Seminario, Ana Lucia — University of Washington
- Study coordinator: Seminario, Ana Lucia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.