How HIV affects liver damage in people with hepatitis B
Cooperative mechanisms of HIV-enhanced liver fibrogenesis in HBV Coinfection
This study looks at how HIV makes liver damage worse in people who also have chronic hepatitis B, with the goal of finding better treatments for those dealing with both infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10651715 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which HIV infection accelerates liver damage in individuals who also have chronic hepatitis B virus (HBV) infection. The study utilizes advanced laboratory models to explore how HIV enhances HBV replication and contributes to liver fibrosis, a serious condition that can lead to cirrhosis or liver cancer. By understanding these interactions, the research aims to identify potential therapeutic targets that could improve treatment outcomes for patients with both infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are co-infected with HIV and chronic hepatitis B virus.
Not a fit: Patients who are solely infected with hepatitis B virus without HIV or those with other liver diseases unrelated to HIV or HBV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with HIV and HBV co-infection, potentially reducing liver damage and associated complications.
How similar studies have performed: Previous research has shown promising results in understanding liver fibrosis in other viral co-infections, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chung, Raymond T — Massachusetts General Hospital
- Study coordinator: Chung, Raymond T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.