How HIV affects intestinal cell death through immune cell metabolism
Immunometabolic regulation of CD8+ T cell mediated intestinal epithelial cell death in people with HIV (PWH)
This study is looking at how HIV affects gut health by causing inflammation and damage to the cells in your intestines, and it aims to understand how certain immune cells might be involved in this process, helping to improve the health of people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10884267 on NIH RePORTER |
What this research studies
This research investigates the impact of HIV on intestinal health, focusing on how the virus causes inflammation and damage to gut cells. It aims to understand the mechanisms behind this damage by analyzing tissue samples from individuals with HIV and using advanced laboratory models. The study will explore how immune cells, specifically CD8+ T cells, may contribute to the death of intestinal epithelial cells by altering their metabolism. By uncovering these processes, the research seeks to provide insights into the ongoing health challenges faced by people living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing gastrointestinal issues or related health complications.
Not a fit: Patients who are HIV-negative or those who do not have gastrointestinal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving gut health and overall well-being in people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding immune cell interactions in HIV, but this specific approach to studying intestinal epithelial cell death is relatively novel.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kwon, Douglas — Massachusetts General Hospital
- Study coordinator: Kwon, Douglas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.