How HIV affects children's immunity to tuberculosis
The effect of HIV exposure and infection on immunity to TB in children
This study is looking at how being exposed to HIV before birth affects how well children respond to the BCG vaccine that protects against tuberculosis (TB), so we can find better ways to help these kids stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10540681 on NIH RePORTER |
What this research studies
This research investigates the impact of HIV exposure and infection on the immune responses of children to tuberculosis (TB). It focuses on understanding how being exposed to HIV in utero influences the effectiveness of the BCG vaccine, which is given to newborns to protect against severe TB. The study will analyze immune responses in children who are HIV-exposed but uninfected, as well as those who are infected, to uncover mechanisms that may increase their susceptibility to TB. By examining these immune responses, the research aims to identify potential interventions to improve TB prevention in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are children who have been exposed to HIV in utero, including both HIV-exposed uninfected and HIV-infected infants.
Not a fit: Patients who are not children or who have not been exposed to HIV may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing tuberculosis in children exposed to HIV.
How similar studies have performed: Previous research has shown that BCG vaccination can provide non-specific immune benefits, suggesting that this approach may yield valuable insights into TB prevention in HIV-exposed children.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: John-Stewart, Grace C. — University of Washington
- Study coordinator: John-Stewart, Grace C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.