How HIV affects breast cancer in women
The impact of HIV on the breast cancer tumor microenvironment
This study is looking at how HIV affects breast cancer in women living with HIV in Uganda, focusing on how the virus might change the way the immune system interacts with tumors, which could lead to more aggressive cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10472711 on NIH RePORTER |
What this research studies
This research investigates the impact of HIV on the tumor microenvironment of breast cancer in women living with HIV in Uganda. It aims to understand how HIV-related immune dysfunction influences breast cancer development and progression. By analyzing tumor tissue and blood samples, the study will identify specific immune features associated with HIV that may contribute to more aggressive cancer behavior. The research employs advanced techniques like flow cytometry and transcriptomic profiling to characterize immune cells and their interactions within the tumor environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are women living with HIV who have been diagnosed with breast cancer.
Not a fit: Patients who do not have HIV or breast cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for breast cancer in women living with HIV.
How similar studies have performed: While the intersection of HIV and breast cancer is a relatively novel area of investigation, similar studies have shown promising results in understanding immune interactions in cancer.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Menon, Manoj P — Fred Hutchinson Cancer Center
- Study coordinator: Menon, Manoj P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.