How HIV-1 spreads between cells and triggers immune responses
Activation of type I interferon production in human immune cells by cell-to-cell transmission of HIV-1
['FUNDING_R15'] · ALBANY COLLEGE OF PHARMACY · NIH-11190261
This study is looking at how HIV-1 spreads between immune cells and triggers the body's defense system, focusing on a key pathway that helps detect the virus, to find ways to boost immune responses in people living with HIV.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBANY COLLEGE OF PHARMACY (nih funded) |
| Locations | 1 site (ALBANY, UNITED STATES) |
| Trial ID | NIH-11190261 on ClinicalTrials.gov |
What this research studies
This research investigates how HIV-1, a virus that causes AIDS, spreads between immune cells and activates the body's immune response. The study focuses on the role of a specific signaling pathway called cGAS/STING, which is crucial for detecting viral infections. By using cell-based models, researchers aim to understand how direct cell-to-cell transmission of HIV-1 leads to the production of important immune signaling molecules called interferons. This could provide insights into improving immune responses in individuals living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are interested in understanding immune responses related to their condition.
Not a fit: Patients who are not infected with HIV or those who have already achieved viral suppression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of HIV infection and lead to better therapeutic strategies for managing HIV/AIDS.
How similar studies have performed: Previous research has shown that understanding immune responses to viral infections can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
ALBANY, UNITED STATES
- ALBANY COLLEGE OF PHARMACY — ALBANY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHI, BINSHAN — ALBANY COLLEGE OF PHARMACY
- Study coordinator: SHI, BINSHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.