How HIV-1 is slowed by a lysosome-targeting compound
Official title: Mechanisms of HIV-1 inhibition by the lysosome modulating compound bafilomycin A1
Funded at Meharry Medical College · NIH-11391020 · Data updated 2026-11-12
A small study tests a compound that blocks HIV-1 growth by messing with lysosomes, with the goal of finding new ways to limit the virus in people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Meharry Medical College NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 11, 2025 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $145,500 |
| NIH project number | 5R16AI192040-02 |
| Project ID | NIH-11391020 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with HIV-1 who may benefit from future therapies targeting lysosome pathways, or who could participate in related future studies.
✕Less likely to help
People with HIV-1 who do not respond to lysosome-targeted approaches or whose disease biology does not involve lysosome pathways may see little benefit.
What this research studies
This project looks at how HIV-1 interacts with the cell’s lysosome system and whether blocking lysosome function can stop the virus from multiplying. Researchers will test compounds that disrupt lysosome activity to see how they affect HIV-1 replication in relevant cellular models. The work aims to clarify conflicting findings about lysosome inhibitors and HIV-1, and to identify promising approaches for future therapies. If the approach proves effective, it could guide the development of new strategies to limit HIV infection at the cellular level.
Why it matters
Potential benefit: If successful, this work could inform new therapeutic angles to slow or prevent HIV-1 replication by targeting lysosome-related pathways.
How similar studies have gone: Previous work suggests lysosome pathways influence HIV-1 replication, but results are mixed and further clarification is needed.
Where this research is happening
-
Meharry Medical College
Nashville, United States Active
Researchers
- Principal investigator: Song, Byeongwoon — Meharry Medical College
- Study coordinator: Song, Byeongwoon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.