How HIV-1 and SARS-CoV-2 interact to affect brain inflammation
Official title: Intersection of HIV-1 Tat and SARS-CoV-2 S1 on neuroinflammation
Funded at University of North Dakota · NIH-10755919 · Data updated 2026-11-12
This study is looking at how HIV-1 and the virus that causes COVID-19 might work together to cause brain problems after getting COVID-19, especially for people who have HIV-1, to find better ways to help manage those symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Dakota NIH-funded |
| Lab location | 1 site (Grand Forks, United States) |
| Project start | August 28, 2023 |
| Project end | August 27, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,971,308 |
| NIH project number | 1RF1MH134592-01 |
| Project ID | NIH-10755919 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV-1 who have experienced neurological symptoms following COVID-19.
✕Less likely to help
Patients who do not have HIV-1 or have not experienced neurological complications from COVID-19 may not benefit from this research.
What this research studies
This research investigates the relationship between HIV-1 and SARS-CoV-2, particularly focusing on how these viruses may contribute to neurological complications following COVID-19. The study aims to understand the mechanisms by which viral factors from both HIV-1 and SARS-CoV-2 interact within brain cells, potentially leading to neuroinflammation. By examining these interactions at a cellular level, the research seeks to uncover new insights that could help in managing neurological symptoms associated with COVID-19, especially in individuals living with HIV-1.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of neurological complications arising from COVID-19, particularly for patients with HIV-1.
How similar studies have gone: While the intersection of HIV-1 and SARS-CoV-2 is a relatively novel area of investigation, previous studies have shown that understanding viral interactions can lead to significant advancements in treatment approaches.
Where this research is happening
-
University of North Dakota
Grand Forks, United States Active
Researchers
- Principal investigator: Chen, Xuesong — University of North Dakota
- Study coordinator: Chen, Xuesong
Related research
Other NIH-funded projects on the same topics.
-
How COVID-19 infection and genes may influence memory and dementia risk
This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.
-
Understanding flu and COVID-19 vaccine responses in people and in the lab
Researchers at Stanford explore how flu and COVID-19 vaccines work in people and in lab tests to improve protection for adults.
-
Oral small molecule inhibitors to block SARS-CoV-2 RNA replication
A Stanford-led project tests a pill that could stop SARS-CoV-2 and related viruses from copying their RNA inside infected cells.
-
Outpatient antiviral cocktails to fight SARS-CoV-2 and future RNA viruses
Researchers at Stanford are developing outpatient antiviral cocktails that could be used easily outside the hospital to treat COVID-19 and future RNA virus infections.
-
Inhibitors for SARS-CoV-2 Proteases to Block Viral Replication
A patient-facing program aims to discover and optimize small molecules that block key SARS-CoV-2 enzymes, potentially reducing viral replication.
-
How different COVID-19 vaccines shape immune responses
This project compares immune reactions after mRNA and adenoviral COVID-19 vaccines to learn how long protection lasts and why some people get breakthrough infections or side effects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.