How HIV-1 and SARS-CoV-2 interact to affect brain inflammation
Intersection of HIV-1 Tat and SARS-CoV-2 S1 on neuroinflammation
This study is looking at how HIV-1 and the virus that causes COVID-19 might work together to cause brain problems after getting COVID-19, especially for people who have HIV-1, to find better ways to help manage those symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Dakota NIH-funded |
| Lab location | 1 site (Grand Forks, United States) |
| Project ID | NIH-10755919 on NIH RePORTER |
What this research studies
This research investigates the relationship between HIV-1 and SARS-CoV-2, particularly focusing on how these viruses may contribute to neurological complications following COVID-19. The study aims to understand the mechanisms by which viral factors from both HIV-1 and SARS-CoV-2 interact within brain cells, potentially leading to neuroinflammation. By examining these interactions at a cellular level, the research seeks to uncover new insights that could help in managing neurological symptoms associated with COVID-19, especially in individuals living with HIV-1.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV-1 who have experienced neurological symptoms following COVID-19.
Not a fit: Patients who do not have HIV-1 or have not experienced neurological complications from COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of neurological complications arising from COVID-19, particularly for patients with HIV-1.
How similar studies have performed: While the intersection of HIV-1 and SARS-CoV-2 is a relatively novel area of investigation, previous studies have shown that understanding viral interactions can lead to significant advancements in treatment approaches.
Where this research is happening
Grand Forks, United States
- University of North Dakota — Grand Forks, United States (Active)
Researchers
- Principal investigator: Chen, Xuesong — University of North Dakota
- Study coordinator: Chen, Xuesong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.