How HIV-1 affects brain cells and contributes to neurotoxicity
The interplay between HIV-1 and amyloid precursor protein in infection and neurotoxicity
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-11042138
This study is looking at how HIV-1 affects brain cells and immune cells in the brain, hoping to find new ways to help people with cognitive issues related to HIV, like memory problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11042138 on ClinicalTrials.gov |
What this research studies
This research investigates the interaction between HIV-1 and brain cells, particularly focusing on how the virus infects immune cells in the central nervous system. It aims to understand the replication strategies of HIV-1 in these cells and the resulting neurotoxic environment that can lead to cognitive disorders in patients. By studying the cytokines and toxic products secreted by infected brain-resident immune cells, the research seeks to uncover potential targets for new treatments. The findings could provide insights into the mechanisms behind HIV-1-associated dementia and other neurocognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1, particularly those experiencing cognitive difficulties or neurocognitive disorders.
Not a fit: Patients who are not infected with HIV-1 or those without any cognitive impairments related to HIV-1 are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent or treat neurocognitive disorders in individuals living with HIV-1.
How similar studies have performed: Previous research has shown promising results in understanding the neurotoxic effects of HIV-1, but this specific approach to studying brain-resident immune cells is relatively novel.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAGHAVI, MOJGAN HOSSEINI — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: NAGHAVI, MOJGAN HOSSEINI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome, Alzheimer disease dementia, Alzheimer syndrome