How histone modifications affect gene regulation in cancer
Official title: Mechanisms of SAGA Regulation by Histone Crosstalk
Funded at Johns Hopkins University · NIH-10998572 · Data updated 2026-11-12
This study is looking at how a special protein complex called SAGA helps control gene activity in cancers linked to the c-myc gene, with the hope of finding new ways to treat these cancers that could help patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 1F32GM156005-01 |
| Project ID | NIH-10998572 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with c-myc driven cancers who may benefit from targeted therapies.
✕Less likely to help
Patients with cancers not driven by c-myc or those with non-cancerous conditions may not receive benefits from this research.
What this research studies
This research investigates the role of the SAGA complex, which modifies histones to regulate gene transcription, particularly in the context of cancers driven by the c-myc gene. The project aims to understand how the SAGA complex's acetylation and deubiquitination activities interact with chromatin, potentially revealing new therapeutic targets. By using advanced techniques like cryo-electron microscopy, the research will explore the structural dynamics of the SAGA complex and its components. Patients may benefit from insights gained about how these processes can be manipulated for cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating c-myc driven cancers.
How similar studies have gone: Previous research has shown promising results in targeting histone modifications for cancer treatment, indicating that this approach has potential.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Fields, James Kemper — Johns Hopkins University
- Study coordinator: Fields, James Kemper
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.