How Hippo pathway affects estrogen receptor function in breast cancer
Functional interplay between Hippo and estrogen receptor ESR1
This study is looking at how a specific pathway in our cells affects a key protein involved in the growth of certain breast cancers, especially in patients who have stopped responding to hormone treatments, with the goal of finding better ways to help those patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11042246 on NIH RePORTER |
What this research studies
This research investigates the relationship between the Hippo signaling pathway and the estrogen receptor ESR1, which is crucial for the growth of estrogen receptor-positive breast cancers. The study aims to understand how the Hippo pathway regulates ESR1 expression and its implications for breast cancer treatment, particularly in cases where patients have developed resistance to hormone therapy. By exploring the molecular mechanisms involved, the research seeks to identify new therapeutic strategies that could improve treatment outcomes for patients with hormone-resistant breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with estrogen receptor-positive breast cancer, particularly those who have not responded to standard hormone therapies.
Not a fit: Patients with non-estrogen receptor-positive breast cancer or those who have not undergone hormone therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with hormone-resistant breast cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of the Hippo pathway in cancer biology, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Yang, Jing — University of California, San Diego
- Study coordinator: Yang, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.