NIH-funded research R01 grant

How high-potency cannabis products impact mental health and social functioning in adolescents

Official title: Effects of High Potency Cannabis Products on Mental Health and Psychosocial Functioning

Funded at University of Colorado Denver · NIH-11049106 · Data updated 2026-11-12

This study is looking at how using strong cannabis products affects the mental health and social life of teenagers and young adults aged 12 to 20, so we can better understand the impact of these products on their well-being over time.

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Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Colorado Denver
NIH-funded
Lab location1 site (Aurora, UNITED STATES)
Project startMay 15, 2023
Project endMarch 31, 2028
Funding year2025
Award (this year)$671,243
NIH project number5R01DA057894-03
Project IDNIH-11049106 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adolescents aged 12-20 who use or have used cannabis products, particularly those with high THC concentrations.

Less likely to help

Patients who do not use cannabis or are outside the age range of 12-20 may not receive any benefit from this research.

What this research studies

This research investigates the effects of high-potency cannabis products, particularly concentrates with THC levels significantly higher than traditional cannabis, on mental health and psychosocial functioning in adolescents aged 12-20. By utilizing a longitudinal twin study, participants will be assessed over time to understand the relationship between cannabis use and mental health outcomes. The study aims to clarify how different cannabis products influence cannabinoid exposure and its subsequent effects on psychological well-being and social interactions.

Why it matters

Potential benefit: If successful, this research could provide valuable insights into the mental health risks associated with high-potency cannabis use, helping to inform public health policies and treatment approaches for adolescents.

How similar studies have gone: While there is existing research on cannabis use and mental health, this study's focus on high-potency products and its longitudinal design offers a novel approach to understanding these effects.

Where this research is happening

  • University of Colorado Denver
    Aurora, United States
    Active

Researchers

  • Principal investigator: Hopfer, Christian J — University of Colorado Denver
  • Study coordinator: Hopfer, Christian J

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.