How high blood sugar affects the immune response to pelvic mesh implants in women
Official title: Impact of hyperglycemic memory on innate immune response to urogynecologic mesh
Funded at Ohio State University · NIH-11223894 · Data updated 2026-11-12
This study is looking at how high blood sugar levels might affect the immune system of women getting mesh implants for issues like urinary incontinence and pelvic organ prolapse, especially those with diabetes, to help improve their recovery and reduce complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | December 5, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $681,503 |
| NIH project number | 7R01HD108666-03 |
| Project ID | NIH-11223894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adult women with diabetes who are considering or have undergone urogynecologic mesh implantation.
✕Less likely to help
Patients without diabetes or those not undergoing urogynecologic procedures may not benefit from this research.
What this research studies
This research investigates the impact of hyperglycemic memory on the immune response of women receiving urogynecologic mesh implants for conditions like stress urinary incontinence and pelvic organ prolapse. It focuses on understanding how prolonged high blood sugar levels can lead to complications such as mesh exposure and chronic pain, particularly in women with diabetes. The study aims to uncover the underlying mechanisms, specifically how hyperglycemia may leave lasting changes in bone marrow cells that affect immune function. By analyzing these effects, the research seeks to improve patient outcomes and reduce healthcare costs associated with mesh-related complications.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for women with diabetes undergoing pelvic mesh procedures, ultimately improving their quality of life.
How similar studies have gone: While the specific focus on hyperglycemic memory in relation to urogynecologic mesh is novel, related studies have shown that glycemic control significantly impacts surgical outcomes in diabetic patients.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Liang, Rui — Ohio State University
- Study coordinator: Liang, Rui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.