How high blood pressure and a fatty diet affect brain function in menopausal women.
Impact of hypertension and high-fat diet on mechanisms by which estradiol affects cortical synaptic plasticity.
This study is looking at how high blood pressure and a fatty diet affect the way a hormone called estradiol works in the brain, especially during menopause, to see if it can help protect memory and thinking skills in women around midlife.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11032852 on NIH RePORTER |
What this research studies
This research investigates how hypertension and a high-fat diet influence the effects of estradiol on brain function, particularly in relation to cognitive decline during menopause. It focuses on understanding the mechanisms behind neurovascular coupling, which is essential for maintaining healthy brain activity. By examining these interactions, the study aims to identify critical periods for hormone therapy that could help protect cognitive abilities in women at midlife. The research employs advanced techniques to analyze brain activity and hormonal influences in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are menopausal women experiencing cognitive impairments or at risk for Alzheimer's disease due to hypertension or high-fat diets.
Not a fit: Patients who are not menopausal or do not have hypertension or high-fat diet-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cognitive decline in menopausal women, potentially reducing the risk of Alzheimer's disease.
How similar studies have performed: Previous research has shown that hormone therapy can be beneficial for cognitive function in menopausal women, suggesting that this approach may yield significant insights.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Mostany, Ricardo — Tulane University of Louisiana
- Study coordinator: Mostany, Ricardo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.