How high-altitude mice adapt to low oxygen levels
Genomic and physiological mechanisms of hypoxia adaptation in high-altitude mice
This study looks at special mice that live in high places and how they manage to thrive in low-oxygen areas, hoping to find helpful information for people who struggle with breathing issues or other conditions related to not getting enough oxygen.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project ID | NIH-10899536 on NIH RePORTER |
What this research studies
This research investigates how certain mice that live at high altitudes have developed unique biological mechanisms to survive in low-oxygen environments. By studying these adaptations, researchers aim to uncover insights that could be relevant to human health, particularly for conditions that involve oxygen deprivation. The project combines genetic analysis and physiological experiments to understand how these mice perform physically under hypoxic conditions, comparing species that thrive at different altitudes. This could lead to a better understanding of how to manage similar challenges in humans.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with respiratory or cardiovascular conditions that affect oxygen utilization.
Not a fit: Patients who do not have any conditions related to oxygen deprivation or who live at sea level may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to oxygen deprivation in humans.
How similar studies have performed: Other research has shown success in understanding hypoxia adaptation in various species, suggesting that this approach could yield valuable insights.
Where this research is happening
Lincoln, United States
- University of Nebraska Lincoln — Lincoln, United States (Active)
Researchers
- Principal investigator: Storz, Jay — University of Nebraska Lincoln
- Study coordinator: Storz, Jay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.