How hexavalent chromium causes cancer through long non-coding RNA changes
Official title: Mechanism of Hexavalent Chromium Carcinogenesis Role of Long Non-Coding RNA Dysregulation
Funded at State University New York Stony Brook · NIH-10823032 · Data updated 2026-11-12
This study is looking at how being around hexavalent chromium, a harmful substance, might lead to cancer by changing certain molecules in our cells, and it aims to find new ways to understand and treat cancer for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $358,875 |
| NIH project number | 7R01ES029942-05 |
| Project ID | NIH-10823032 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to hexavalent chromium and are at risk for developing related cancers.
✕Less likely to help
Patients who have not been exposed to hexavalent chromium or do not have a history of related cancers may not benefit from this research.
What this research studies
This research investigates how exposure to hexavalent chromium, a known environmental carcinogen, leads to cancer development. It focuses on the role of long non-coding RNAs, which are molecules that regulate gene expression and may be altered by chromium exposure. The study aims to understand the epigenetic changes caused by chromium, particularly how these changes contribute to cancer progression. By examining these mechanisms, the research seeks to uncover new insights into cancer biology and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for cancers associated with chromium exposure.
How similar studies have gone: While the specific focus on long non-coding RNAs in chromium carcinogenesis is novel, previous studies have shown success in understanding the carcinogenic effects of environmental toxins.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Yang, Chengfeng — State University New York Stony Brook
- Study coordinator: Yang, Chengfeng
Related research
Other NIH-funded projects on the same topics.
-
Understanding how oral microbes interact at the single-cell level
Aimed at uncovering how bacteria in the mouth stick together and influence each other, using advanced imaging to reveal functional connections at the microscopic level.
-
Cellular and circuit-level mechanisms of HIV/NRTI-related pain in the context of opioids
This NIH grant explores how HIV medicines (NRTIs) and opioids may combine to cause chronic pain, aiming to help people living with HIV who experience pain.
-
Using a dye to see how kidneys work and how transporters act
A new, simple dye-based test could help doctors measure kidney tubular function and transporter activity more accurately in people with acute kidney problems.
-
Interneuronal aging in trauma-exposed World Trade Center responders
A study in WTC responders with PTSD will look at brain interneuron health using advanced imaging and proteins to understand how PTSD may affect aging brains.
-
Dynamic PTSD-Related Cognitive Risk in Aging WTC Responders
This project follows World Trade Center responders as they age to understand how PTSD symptoms relate to changes in thinking skills over time.
-
How CHIKV viruses adapt to mosquitoes and cause disease in people
This project explores how the chikungunya virus changes to become better at infecting mosquitoes and causing disease in humans, with the goal of understanding how to prevent transmission and illness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.