How hexavalent chromium causes cancer through long non-coding RNA changes
Mechanism of Hexavalent Chromium Carcinogenesis Role of Long Non-Coding RNA Dysregulation
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-10823032
This study is looking at how being around hexavalent chromium, a harmful substance, might lead to cancer by changing certain molecules in our cells, and it aims to find new ways to understand and treat cancer for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-10823032 on ClinicalTrials.gov |
What this research studies
This research investigates how exposure to hexavalent chromium, a known environmental carcinogen, leads to cancer development. It focuses on the role of long non-coding RNAs, which are molecules that regulate gene expression and may be altered by chromium exposure. The study aims to understand the epigenetic changes caused by chromium, particularly how these changes contribute to cancer progression. By examining these mechanisms, the research seeks to uncover new insights into cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to hexavalent chromium and are at risk for developing related cancers.
Not a fit: Patients who have not been exposed to hexavalent chromium or do not have a history of related cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for cancers associated with chromium exposure.
How similar studies have performed: While the specific focus on long non-coding RNAs in chromium carcinogenesis is novel, previous studies have shown success in understanding the carcinogenic effects of environmental toxins.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, CHENGFENG — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: YANG, CHENGFENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Cancer Causing Agents