How herpes simplex virus affects the body's DNA damage response and protein changes.
Official title: Manipulation of the DNA damage response and the proteome on viral genomes during Herpes Simplex Virus (HSV) infection
Funded at Children's Hosp of Philadelphia · NIH-11026740 · Data updated 2026-11-12
This study is looking at how the herpes virus affects our body's natural defenses against DNA damage while it’s infecting us, which could help us find new ways to treat the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | November 15, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $651,832 |
| NIH project number | 1R01AI187335-01 |
| Project ID | NIH-11026740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with herpes simplex virus infections, particularly those experiencing recurrent outbreaks.
✕Less likely to help
Patients with other viral infections or those who do not have herpes simplex virus may not benefit from this research.
What this research studies
This research investigates how the herpes simplex virus (HSV) interacts with the body's DNA damage response mechanisms during infection. It focuses on understanding how the virus manipulates these cellular processes to enhance its replication. By utilizing advanced proteomics techniques, the study aims to identify the specific signaling networks and protein changes that occur when the virus infects host cells. This could lead to new insights into viral behavior and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies that more effectively combat herpes simplex virus infections.
How similar studies have gone: Previous research has shown success in understanding viral manipulation of host cellular processes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Weitzman, Matthew D. — Children's Hosp of Philadelphia
- Study coordinator: Weitzman, Matthew D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.