How helper (CD4+) T cells form memory after malaria
Development and function of CD4+ memory T cells during malaria
This project looks at how CD4+ 'helper' T cells build lasting immune memory after malaria infection to help people affected by the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11252515 on NIH RePORTER |
What this research studies
Researchers use advanced cell and molecular genetic tools to study parasite-specific CD4+ helper T cells that support antibody responses after malaria. They will examine how parasite products like hemozoin influence the creation, function, and long-term survival of memory CD4+ T cells. High-resolution lab techniques will track these immune cells over time to understand why strong, lasting immunity rarely develops after infection. The team aims to reveal mechanisms that could be targeted by vaccines or immune-based therapies.
Who could benefit from this research
Good fit: People who have had malaria or who are willing to donate blood samples for immune research would be the most relevant participants.
Not a fit: This basic laboratory research is unlikely to provide direct or immediate treatment benefits to people needing urgent malaria care.
Why it matters
Potential benefit: If successful, this work could inform vaccines or immune therapies that produce stronger and longer-lasting protection against malaria.
How similar studies have performed: Related cellular and genetic methods have clarified immune memory in other infections, but CD4+ memory in malaria remains incompletely understood and is still an active basic-research area.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Butler, Noah Sullivan — University of Iowa
- Study coordinator: Butler, Noah Sullivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.